The setting and the system -- Money for science : never enough -- Elusive industrial angels -- Commercialize! It's the law -- Changing attitudes -- The price of profits -- Conflicts and interests -- A new regime -- As seen from the inside--six conversations -- Success and remorse -- A congenial partnership -- When the rules change in midstream -- Profits and principles -- Generations apart -- The journals revolt -- Fixing the system -- What's right and wrong, and how to make it better -- Epilogue : a parable for our time.