Introduction: Substance use and abuse in South Africa / Dan J. Stein ... [et al.]. Epidemiology and symptomatology. Epidemiology of substance use and abuse in South Africa / Shandir Ramlagan and Karl Peltzer -- The clinical presentation of substance-related disorders in South Africa / Don Wilson, Henk Temmingh and Allanah Wilson -- Development consequences of prenatal drug and alcohol exposure / Colleen M. Adnams -- Women and alcohol / Bronwyn Meyers and Bravanisha Vythilingum. Neuroscience and psychiatry. Addiction as virtual seeking: evolutionary insights into addiction / David Kibel and Dan J. Stein -- Genetics and molecular biology / Shareefa Dalvie and Fleur Howells -- Brain imaging and neural circuitry in methamphetamine users / Ernesta M. Meintjes, Anne Uhlmann and Paul Carey -- Affective neuroscience of methamphetamine abuse / Susan Malcolm-Smith ... [et al.] -- Neurocognitive effects of alcohol abuse and dependence / Kevin G.T. Thomas and Helen L. Ferrett -- Neuropsychoanalytic notes on addiction / Mark Solms, Eleni Pantelis and Jaak Panksepp -- Decision-making and substance abuse: a South African perspective / Don Ross -- Animal models of substance abuse / Vivienne A. Russell, Jacqueline Dimatelis and William M.U. Daniels. Intervention and policy. Youth and substances / Neo K. Morojele ... [et al.] -- Evaluated interventions to prevent substance abuse among young South Africans / Cleo Protogerou, Alan J. Fisher and Neo K. Morojele -- Interpersonal violence in South Africa and substance misuse: connections and approaches to prevention / Catherine L. Ward -- Substance abuse, stigma and health literacy: a conceptual framework / Katherine R. Sorsdahl and Dan J. Stein -- Addiction: philosophy and ethics / Willem Pienaar -- Clinical treatment of substance use disorders in South Africa / Henk Tremmingh and Bronwyn Myers -- Substance abuse policy in South Africa / Crick Lund and Noxolo Hewana.