400 years in the future disease has wiped out the majority of the earth's population except for one walled city-state, Bregna, ruled by a congress of scientists. Aeon Flux is an assassin working for the Monicans, a group of rebels trying to overthrow the government. When Aeon is sent on a mission to kill the government's leader, she uncovers a world of secrets, which makes her question everything she thought she knew.