Forensic DNA typing : biology, technology, and genetics of STR markers

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Title:

Author:

Butler, John M. (John Marshall), 1969-

ISBN:

9780121479527

Personal Author:

Butler, John M. (John Marshall), 1969-

Edition:

2nd ed.

Publication Information:

London : Elsevier Academic Press, c2005.

Physical Description:

xvii, 660 p. : ill. (some col.) ; 26 cm.

General Note:

Previous ed.: San Diego, Calif. : Academic Press, c2001.

Contents:

1. Overview and history of DNA typing -- 2. DNA biology review -- 3. Sample collection, DNA extraction and DNA quantitation -- 4. The polymerase chain reaction (DNA amplification) -- 5. Commonly used short tandem repeat markers and commercial kits -- 6. Biology of STRs : stutter products, non-template addition, microvariants, null alleles and mutation rates -- 7. Forensic issues : degraded DNA, PCR inhibition, contamination, mixed samples and low copy number -- 8. Single nucleotide polymorphisms and other bi-allelic markers -- 9. Y chromosome DNA testing -- 10. Mitochondrial DNA analysis -- 11. Non-human DNA testing and microbial forensics -- 12. DNA separation methods : slab gel and capillary electrophoresis -- 13. DNA detection methods : fluorescent dyes and silver-staining -- 14. Instrumentation for STR typing : ABI 310, ABI 3100, FMBIO systems -- 15. STR genotyping issues -- 16. Laboratory validation -- 17. New technologies, automation, and expert systems -- 18. Combined DNA index system (CODIS) and the use of DNA databases -- 19. Basic genetic principles, statistics, and probability -- 20. STR population database analyses -- 21. Profile frequency estimates, likelihood ratios, and source attribution -- 22. Approaches to statistical analysis of mixtures and degraded DNA -- 23. Kinship and parentage testing -- 24. Mass disaster DNA victim identification -- App. I. Reported STR alleles : sizes and sequences -- App. II. U.S. population data - STR allele frequencies -- App. III. Suppliers of DNA analysis equipment, products, OR services -- App. IV. DNA advisory board quality assurance standards -- App. V. DAB recommendations on statistics -- App. VI. NRC II recommendations -- App. VII. Example DNA cases.

Abstract:

"This book examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century."--BOOK JACKET.

Subject Term:

DNA fingerprinting.

DNA -- Physiology.

Forensic genetics.

Polymerase chain reaction.

DNA -- Synthesis.

Copies:

Available:*

Library	Material Type	Item Barcode	Shelf Number	Copy	Status
Searching... 1:IIEMSA	1:GEN-BOOK	33168025489358	614.1 B985F 2005	1	Searching... Unknown

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Summary

Forensic DNA Typing, Second Edition, is the only book available that specifically covers detailed information on mitochondrial DNA and the Y chromosome. It examines the science of current forensic DNA typing methods by focusing on the biology, technology, and genetic interpretation of short tandem repeat (STR) markers, which encompass the most common forensic DNA analysis methods used today.

The book covers topics from introductory level right up to cutting edge research. High-profile cases are addressed throughout the text, near the sections dealing with the science or issues behind these cases. Ten new chapters have been added to accommodate the explosion of new information since the turn of the century. These additional chapters cover statistical genetic analysis of DNA data, an emerging field of interest to DNA research. Several chapters on statistical analysis of short tandem repeat (STR) typing data have been contributed by Dr. George Carmody, a well-respected professor in forensic genetics. Specific examples make the concepts of population genetics more understandable.

This book will be of interest to researchers and practitioners in forensic DNA analysis, forensic scientists, population geneticists, military and private and public forensic laboratories (for identifying individuals through remains), and students of forensic science.