The metabolic pathway engineering handbook : tools and applications

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Title:

Author:

Smolke, Christina D.

ISBN:

9781420077650

Publication Information:

Physical Description:

1 volume (various pagings) : illustrations (some color) ; 26 cm

Contents:

Evolutionary engineering of industrially important microbial phenotypes / Stephen S. Fong -- Improving protein functions by directed evolution / Nikhil U. Nair and Huimin Zhao -- Engineering DNA and RNA regulatory regions through random mutagenesis and screening / Ichiro Matsumura, Sean A. Lynch, and Justin P. Gallivan -- Evolving pathways and genomes for the production of natural and novel compounds / Ethan T. Johnson and Claudia Schmidt-Dannert -- Models predicting optimized strategies for protein evolution / Jonathan J. Silberg and Peter Q. Nguyen -- Low-copy number plasmids as artificial chromosomes / Kristala L. Jones Prather -- Chromosomal engineering strategies / Kenan C. Murphy -- Regulating gene expression through engineered RNA technologies / Maung Nyan Win and Christina D. Smolke -- Tools designed to regulate translational efficiency / Claes Gustafsson -- Metabolic engineering of the secretory processing pathway in eukaryotes / Mohak Mhatre, Maira P. Pellegrini, and Michael J. Betenbaugh -- Engineering multifunctional enzyme systems for optimized metabolite transfer between sequential conversion steps / Robert J. Conrado, Thomas J. Mansell, and Matthew P. DeLisa.

Practical pathway engineering : demonstration in integrating tools / Sung Kuk Lee and Jay D. Keasling -- Genome-wide technologies : DNA microarrays, phenotypic microarrays, and proteomics / Seh Hee Jang [and others] -- Monitoring and measuring the metabolome / Maria Rowena N. Monton and Tomoyoshi Soga -- Systems biology, genome-scale models, and metabolic engineering / Sang Yup Lee [and others]-- Cell-free systems for metabolic engineering / Kara A. Calhoun and James R. Swartz -- In silico models for metabolic systems engineering / Kumar Selvarajoo [and others] -- GC-MS for metabolic flux analysis / Christophe Wittmann -- Tools for measuring intermediate and product formation / Marco Oldiges -- Use of AEX-HPLC-ESI-MS for 13C-labeling based metabolic flux analysis in Saccharomyces cerevisiae and Penicillium chrysogenum / Wouter A. van Winden [and others] -- Energy and cofactor issues in fermentation and oxyfunctionalization processes / Bruno Bühler [and others] -- Microbial biosynthesis of fine chemicals : an emerging technology / Zachary L. Fowler and Mattheos Koffas -- Applications of metabolic engineering for natural drug discovery / Yi Tang, Suzanne Ma, and Wladyslaw A. Wojcicki -- Metabolic engineering for alternative fuels / Yandi Dharmadi and Ramon Gonzalez.

Abstract:

"The Metabolic Pathway Engineering Handbook : Tools and Applications delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels. Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions."--Publisher's description.

Subject Term:

Genetic engineering -- Handbooks, manuals, etc.

Biosynthesis -- Handbooks, manuals, etc.

Genetic Engineering -- methods.

Added Author:

Copies:

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Library	Material Type	Item Barcode	Shelf Number	Copy	Status
Searching... 1:IIEMSA	1:GEN-BOOK	33168025788692	660.6 S666M 2010	1	Searching... Unknown

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Summary

This second volume of the Metabolic Pathway Engineering Handbook delves into evolutionary tools and gene expression tools for metabolic pathway engineering. It covers applications of emerging technologies including recent research genome-wide technologies, DNA and phenotypic microarrays, and proteomics tools for experimentally determining flux through pathways. This volume also looks at emerging applications for producing fine chemicals, drugs, and alternative fuels.

Christine Smolke, who recently developed a novel way to churn out large quantities of drugs from genetically modified brewer's yeast, is regarded as one of the most brilliant new minds in biomedical engineering. In this handbook, she brings together pioneering scientists from dozens of disciplines to provide a complete record of accomplishment in metabolic pathway engineering. With a wealth of cutting edge research and analysis, this work also serves as an invaluable resource for those seeking to add their own contributions. Organized by topic, this 3000 page reference is available as two volumes that can be purchased individually or as a set .