Global Commons refer to domains that fall outside the direct jurisdiction of sovereign states - the high seas, air, space, and most recently the man-made cyberspace - and thus should be usable by anyone. These domains, even if outside the direct responsibility and governance of sovereign entities, are of crucial interest for the contemporary world order. This book elaborates a practice-based approach to the Global Commons and Flows to critically examine the evolving United States (U.S.) geopolitical strategy and vision. The study starts with the observation that the nature of U.S. power is evolving increasingly towards the recognition that the command over the flows of global interdependence is a central dimension of national power. The study then highlights the emerging security and governance of these flows. In this context, the flows and the underlying global critical infrastucture are emerging as objects of high-level strategic importance. The book pays special attention to one of the least recognized but perhaps even fundamental challenges related to the Global Commons, namely the conceptual and practical challenge of inter-domain relationships-between maritime, air, space, and cyber-flows that brings about not only opportunities but also new vulnerabilities. These complexities cannot be understood through technological means alone but rather the issues needs to be clarified by bringing in the human domain of security.